COOPERATION WITH SLOVAK ACADEMY OF SCIENCES

Joint Research Projects:


  • Project coordinator. The effects of "(±)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester" on viability, reactive radical production, insulin releasing and cytokine-mediated cell death in INS-1 cells. Supported by Gazi University Research Foundation No:01/2011-09. 2011-present.

  • Project coordinator. The effects of SMe1EC2 on endothelial functions, vascular reactivity and protein oxidations in diabetic rats as accelerated aging model. Supported by Ankara University Research Foundation No: 10B336002. 2010-present.

  • Project Leader and the coordinator of Turkish side. "The role of oxidative stress in apoptosis and dysfunction of pancreatic beta cells: The potential protective effect of novel pyridoindole antioxidants". Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Slovak Academy of Sciences, SBAG-SLOVAK-4 No:108S239. 2008-present.

  • COST Action B35, "Lipid Peroxidation Associated Disorders (LPO)". "Oxidative Stress in Endocrine and Autoimmune Disease". 2005-2010.

  • Antioxidants and aldose reductase blockade in prevention of late diabetic complications: study on new pyridoindole derivatives, Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Slovak Academy of Sciences, SBAG-SLOVAK-2 (103S180). 2003-2007.

  • Antioxidants and aldose reductase blockade in prevention of late diabetic complications: study on new pyridoindole derivatives, Supported by TÜBİTAK-Turkish Scientific and Research Council, SBAG-2397 (100S232), Ankara University Research Foundation (2001-08-03-031) and Gazi University Research Foundation, (01-2003/50). 2001-2005.

  • The role of some antioxidant compounds on the treatment of cardiovascular observed in experimental diabetes Supported by Ankara University Research Foundation (98-03-005). 1998-2001.

  
Joint International Publications:


  1. Cumaoğlu A., Rackova L., Stefek M., Kartal M., Maechler P., Karasu C. Effects of olive leaf polyphenols against H2O2 toxicity in insulin secreting ?-cells. Acta Biochimica Polonica 58:45-50, 2011.

  1. Ceylan-Isik A.F., Ari N., Stefek M., Sotnikova R., Ozansoy G., Horakova L., Karasu C. Effects of a Long-Term Treatment with an Antioxidant Pyridoindole on Vascular Responsiveness in Diabetes-Induced Aging Rats. Current Aging Sciences 4:150-157, 2011.

  1. Altınok B., Karadağ A., Özkan T., Sunguroğlu A., Stefek M., Karasu C. Effects of SMe1EC2 on cancer cell lines growth in vitro. III. AntiAging Congress, 02-05 December, Ankara, Rixos Hotel, Turkey. Abstract Book. P.95., 2011.

  1. Cumaoğlu A., Stefek M., Karasu C. Sme1EC2 protects pankreatic beta-cells against cytokine-induced toxicity. III. AntiAging Congress, 02-05 December, Ankara, Rixos Hotel, Turkey. Abstract Book. P.71., 2011.

  1. Stefek M., Karasu C., Or M., Kyselova Z. Eye in Aging and diabetes-effect of antioxidant. III. AntiAging Congress, 02-05 December, Ankara, Rixos Hotel, Turkey. Abstract Book. P.67., 2011.

  1. Cumaoglu A., Stefek M., Bauer V., Ari N., Aricioglu A., Karasu C. Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine. Neuro Endocrinology Letters 31:313-318, 2010.

  1. Rackova L., Snirc V., Jung T., Stefek M., Karasu C., Grune T. Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells. Free Radical Research 43:876-886, 2009.

  1. Rackova L., Cumaoğlu A., Maechler P., Stefek M., Karasu C. (±)-8-metoxy-1,3,4,4A,59B-hexahydro-pyrido 4,3-B indole2-carboxylic acid ethyl ester as a protective agent against H2O2-induced oxidative damage in pancreas beta-cell lines. Türkiye Klinikleri, Journal of Medical Sciences, 29: (5) Suppl. S129, P-4, 2009.

  1. Stefek M., Karasu C. Experimental diabetes as a model of accelerated aging: Matrix collagen modifications. Türkiye Klinikleri, Journal of Medical Sciences, 29: (5) Suppl. S21, 2009.

  1. Karasu C., Stefek M. Synthetic antioxidants as potential medical remedies: an update of the past decade of pyridoindoles. Türkiye Klinikleri, Journal of Medical Sciences, 29: (5) Suppl. S25, 2009.

  1. Cumaoğlu A., Rackova L., Maechler P., Stefek M., Karasu C. Can olive extracts protect insulinoma cells against cytokines-induced cytotoxicity? Türkiye Klinikleri,  Journal of Medical Sciences, 29: (5) Suppl. S-126, S-9, 2009.

  1. Stefek M., Snirc V., Djoubissie P.O., Majekova M., Demopoulos V., Rackova L., Bezakova Z., Karasu C., Carbone V., El-Kabbani O. Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling. Bioorg Med Chem 16:4908-4920, 2008.

  1. Yülek F., Or M., Ozoğul C., Isik A.C., Ari N., Stefek M., Bauer V., Karasu C. Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress. Archhive Medical Reearch 38:503-511, 2007.

  1. Umit Bağriaçik E., Uslu K., Yurtçu E., Stefek M., Karasu C. Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells. Cell Bioogy Inernational 31:979-984, 2007.

  1. Güz G., Öz E., Ulusu N.N., Ömeroglu S., Lortlar N., Demiroğulları B., Stefek M., Karasu C. The effects of stobadine and taurine on renal ischemia/reperfusion injury. 31. FEBS Congress ıstanbul-2006.

  1. Güz G., Ulusu N.N., Öz E., Doğru C., Demiroğulları B., Stefek M., Karasu C. Stobadine and taurine protect rat kidney from ischemia/reperfusion injury. IUPHAR2006, Bejing-China

  1. Bagriacik E.U., Karasu C., Uslu K., Stefek M., Bauer V. Stobadine prevents doxorubicin-induced apoptosis by inhibiting caspase 3 in P815 cells. 31. FEBS Congress ıstanbul-2006.

  1. Gunes A., Ceylan A., Sarioglu Y., Stefek M., Bauer V., Karasu C., The Antioxidants in Diabetes-induced Complications (ADIC) Study Group. Reactive oxygen species mediate abnormal contractile response to sympathetic nerve stimulation and noradrenaline in the vas deferens of chronically diabetic rats: effects of in vivo treatment with antioxidants. Fundamental & Clinical Pharmacology 19:73-79, 2005.

  1. Kyselova Z., Gajdosik A., Gajdosikova A., Ulicna O., Mihalova D., Karasu C., Stefek M. Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. Molecular Vision 11: 56-65, 2005.

  1. Demiryurek AT., Karasu C., Stefek M., Stolc S., Effect of stobadine on leukocyte free radical generation in streptozotocin-diabetic rats: comparison with vitamin E, Pharmacology 70:1-4, 2004.

  1. Ceylan A., Karasu C., Arı N., Stefek M., Stobadine regulates vascular reactivity and blood pressure via the effects on calcium channels in chronically diabetic rat aorta, 12th International Congress on Cardiovascular Pharmacotherapy,  May 7-10, Barcelona, 2003.

  1. Ulusu N.N., Sahilli M., Avcı A., Canbolat O., Ozansoy G., Arı N., Bali M., Stefek M., Stolc S., Gajdosik A., Karasu C., Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E, Neurochemical Research 28: 815-823, 2003.

  1. Karasu C., Turkozkan N., Ceylan A., Çimen B., Arı N., Stefek M., Comparison of stobadine and vitamin E treatments on kidney Na+,K+-ATPase activity, HbA1c and systolic blood pressure of chronically diabetic rats, Diabetes & Metabolism 29:4S303, 2501, 2003.

  1. Karasu C., Avcı A., Canbolat O., Bali M., Ozansoy G., Ceylan A., Stefek M., Comparative effects of stobadine and vitamin E treatments on oxidative stress markers in heart and kidney of streptozotocin-diabetic rats, Free Radical Biology & Medicine, 33(Supp.1): S188, 494, 2002.

  1. Ulusu NN., Ceylan A., Stefek M., Karasu C., Comperative effects of stobadine and vitamin E treatments on activities of glucose-6-phosphate dehydrogenase, 6-phosphoglucınate dehydrogenase and glutathione-S-transferase in aortae of STZ diabetic and control rats, EJB The FEBS Journal 269 (Suppl 1): PS5-041, 2002.

  1. Pekiner B., Ulusu NN., Evcimen ND., Sahilli M., Aktan F., Stefek M., Stolc S., Karasu C., In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+-ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E, Biochimica et Biophysica Acta 1588: 71-78, 2002.

  1. Karasu C., Ulusu N., Avci A., Sahilli K., Canbolat O., Ozansoy G., Ari N., Stefek M., Stolc S., Gajdosik A., Effects of stobadine treatment on pentose phosphate pathway, glutathione-dependent enzymes, superoxide dismutase, and lipid peroxidation in the brain of diabetic rat; Comparison with vitamin E. Diabetologia 44(Suppl.1): A155, 592 2001.


Patent reference data:

Carboxymethylated pyridoindoles, preparation and utilization in therapy as aldose reductase inhibitors  and antioxidants

Inventors:

Štefek M, Šnirc V, Demopoulos V, Djoubissie P, Ra?ková L, Májeková M., Karasu C

Patent application was registered on the 16.9.2005 at  the Slovak Patent Agency under the number  PP 98-2005.


Home | CV | Publications | Projects | Teaching | Reserch| Congress
Brief Biography

Invited Presentations

Awards & Honors

Research Cooperations

Other Professional Activities

Preventive, Regenerative, AntiAging Medicine &
Longevity Sciences

In Media

Photos

Address